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How should you come off weight loss injections?

How should you come off weight loss injections?

If you’re feeling satisfied with your weight loss results, you may consider stopping treatment with weight loss injections (WLIs). It's recommended to taper down through doses, to reduce the risk of side effects and prevent weight gain.

Alexandra Cristina Cowell
Medically reviewed by
Alexandra Cristina Cowell, Writer & Clinical Content Reviewer

But besides reaching your goal, there are other reasons for stopping treatment with WLI. So it’s good to know when to taper down, and what to expect if you need to stop treatment suddenly.

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Medically reviewed by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
on Jul 22, 2025.
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Alexandra Cristina

Last updated on Feb 27, 2026.

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Summary:
  • Gradually stopping injections after reaching your goal weight can help you to avoid side effects and regaining weight.
  • Talk to your doctor once you’ve reached your target weight and maintained it for a few months.
  • Weight loss may slow or stop as your body adjusts to the medication.
  • It’s not recommended to stop injections suddenly, as it can lead to strong hunger and fast weight gain.
  • A healthy diet, regular exercise, and planning are key after stopping.

When should you consider stopping your weight loss medication?

You might think the only time to stop taking a WLI is after you’ve reached your goal weight, but there may be other reasons why you might consider stopping.

You've achieved your goal weight

Once you’ve reached your target weight and have maintained it for a few months, you can discuss with your doctor how to taper off the treatment.

Each person will reach their target weight at a different time; for some, it may take up to a year, while for others, it may take even longer. While public provincial health plans or private insurance providers might have specific criteria for how long they’ll cover weight loss injections, some health experts claim continuing to take them can help sustain weight loss and preserve health benefits.

So there isn’t any specific timeframe on when everyone should stop; only you and your doctor can discuss this after reaching your target weight.

You’re having problematic side effects

It’s very common to get side effects when you start taking a WLI. The most common side effects typically include nausea, vomiting, stomach issues and fatigue. As your body adjusts to the treatment, these side effects should subside. But after each dose increase, you may notice these side effects may worsen again temporarily.

Your clinician will do their best to minimize the risk of side effects. They'll gradually increase your dose, provide tips to manage them, and avoid increasing the dosage until you’re ready.

But if the side effects persist or become severe, you may be advised to discontinue treatment for your overall health. You might be able to try an alternative weight loss medication, likely one that isn’t a GLP-1 – and your clinician will be able to advise you on this.

The long-term cost is too much

Weight loss injections can be expensive. The cost of Wegovy can vary, but on average, a year’s supply of treatment in Canada may reach up to $6,800 CAD without insurance. Zepbound costs over time can sometimes work out a little cheaper, but a year’s supply may still reach approximately $6,400 CAD depending on the maintenance dose.

If you haven’t yet started WLI, try to financially plan for at least 1.5 years of treatment. This duration should provide you with enough time to achieve a significant amount of weight loss – approximately 8.3% mean weight loss achieved with Wegovy and 15.3% with Zepbound by month 12.

Additionally, this timeline will allow you to taper off the medication gradually, which can help prevent side effects and reduce the risk of regaining weight.

The medication has become less effective

WLI can be effective for helping you lose weight. In the first few months, you should notice significant weight loss, but after a year or two, your progress might plateau.

This plateau usually happens for several reasons, including your body adapting to the medication, so it doesn’t have the same effects as it did initially.

Additionally, factors such as your diet and physical activity levels can contribute to this plateau. If you’ve stopped maintaining a calorie deficit or have been less active, you might not see as much of a difference in your weight loss progress.

You feel ‘ready’

If you’re satisfied with your weight loss and feel confident in your ability to maintain the results without further treatment, it might be time to stop your treatment. To help you decide if you’re ready, you might find it helpful to ask yourself:

  • Are you happy with your weight loss results?
  • Are you confident you can sustain this weight loss?
  • Are you physically active a few times a week?
  • Are you following a well-balanced, calorie-controlled diet?

If you answered ‘yes’ to all of these questions, it could be a good time to come off treatment.

How to come off weight loss injections

Your clinician will provide all the information on how to come off weight loss injections, but here’s what the process may look like:

Taper down gradually

The recommended way to come off GLP-1 treatment is to gradually decrease your dose. This will help minimize side effects, and give your body time to adjust to the reduced dose. This will allow you to solidify your healthy habits, like diet and exercise. Tapering off will also help prevent rapid weight gain, which is a challenge for many people after stopping treatment.

The tapering method will differ for each person. Generally, you’ll reduce the dose every few weeks, so it could take approximately four to five months to completely stop.

Why you shouldn’t stop weight loss injections suddenly

Why you shouldn’t stop weight loss injections suddenly

Unless you’ve been advised to by a clinician for medical reasons (such as a drug interaction or side effects), then it generally isn’t recommended to stop using GLP-1 treatment suddenly. Doing so can lead to a big increase in appetite, which significantly increases your risk of weight regain.

GLP-1s promote a feeling of fullness, slow stomach emptying, and decrease appetite. Discontinuing them abruptly can lead to overeating. Many individuals might gain weight after stopping treatment, and stopping suddenly only increases this risk.

Stopping suddenly can also interfere with glucose metabolism and cause high blood sugar levels. This can lead to fatigue, blurred vision, and feeling excessively thirsty.

How to succeed long term

Here are some tips on how to prevent weight regain after stopping treatment.

  • Critically review your diet and exercise habits. If you have behaviours that cause you to overeat, try to change them. For example, if you tend to have a late-night snack, sleep earlier, or if you order out when there’s nothing to eat, consider meal prepping in advance.
  • Be strict with yourself (when you need to be). You should generally eat healthily and work out at least three times a week. But also allowing yourself cheat days can help you have a more sustainable lifestyle.
  • Remind yourself of the bigger picture: Think about why you started this weight loss treatment and how regaining weight will undermine the goal you set for yourself months or years ago.
  • Create a good support network. Allow support from your friends, family, dietitians, doctors, and online communities to help keep you on track.
  • Lastly, be nice to yourself. If you have a bad day of eating or didn’t work out like you hoped, try not to worry too much about it. So long as it doesn’t become part of your regular habits, a couple of bad days shouldn’t affect the progress you’ve been making for several years.
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