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Xenical is a weight loss capsule that stops around one third of the fat that you eat from being processed into the body. It’s a fat binding treatment, which means it helps the body get rid of fat before it’s absorbed.
Orlistat is the active ingredient in Xenical 120mg capsules. Xenical is the branded version of ‘Orlistat’.
Xenical should be used in combination with a low calorie diet and regular exercise, even if it’s just a few minutes a day to get your heart rate up. As well as helping you reach your weight loss goals, exercising regularly can help reduce your risk of heart disease, fractures and breast cancer.[2] Doing regular workouts can also improve your energy, all-round strength, and quality of sleep.
How does Xenical work?
It helps enzymes get rid of fat from the body without absorbing it. It’s very effective for many people who use it, but everyone has the potential of reacting differently to the medication.[1]
Xenical only eliminates fat from your diet; it cannot remove fat that’s already been processed by the body. This is why exercise is so important. If the meal you’re eating contains no fat, Xenical won’t provide any benefits for weight loss.
Is Xenical the right weight loss treatment for me?
Fat binding weight loss products like Xenical are only suitable for people whose BMI is at least 30 (or 28 if you have other risk factors such as high blood pressure or type 2 diabetes). Xenical comes in a capsule, so if capsules are a preferred form of weight loss medication for you, it may be the right fit.
Whether Xenical is the best weight loss product for you will also depend on how prone you are to certain side effects, if you have a particular health condition or if you are currently taking other medication that may interact with Xenical. We’ll take all these things into consideration as part of your consultation, before deciding if it’s a safe and appropriate treatment for you.
This page was written by The Treated Content Team.
This page was medically reviewed by Ms Laurenmarie Cormier on October 14, 2024. Next review due on October 14, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to use Xenical
Take one capsule with each of your three main meals (breakfast, lunch and dinner) every day. You can take it just before, during or up to one hour after your meal. Swallow the capsule whole with water.
Xenical is only effective when you consume dietary fat, so if you miss a main meal or if you have a meal that doesn’t contain any fat, you don’t need to take it.
What to eat when taking Xenical
Xenical should be used alongside a well-balanced, calorie controlled diet that’s rich in fruit and vegetables and contains an average of 30% of calories from fat sources. [1] Your daily intake of carbohydrates, protein and fat should be spread over three meals.
To get the most benefit from Xenical, avoid consuming foods that contain fat, such as chocolate, cookies, and savory snacks between meals.
If I miss a Xenical capsule, what should I do?
If you miss a dose, take it as soon as you remember (so long as this is within one hour of your last meal). You can then continue to take it as you normally would. Don’t take twice the amount to make up for a missed dose.
If you miss several doses, tell your doctor. Don’t make any adjustments to your dose without chatting to a physician about it first, and if you have any other questions, just let them know.
This page was written by The Treated Content Team.
This page was medically reviewed by Ms Laurenmarie Cormier on October 14, 2024. Next review due on October 14, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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There are some things you need to watch out for when using Xenical, and not everyone can use it.
Here’s the official safety info. If there’s something you’re not sure about, let us know.
XenicalOrlistat
Xenical: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Xenical or Orlistat: what’s the difference?
Answer:
Xenical is the branded treatment, so it’s more well known than Orlistat. Orlistat, as is usually the case with generic treatments, is a bit cheaper. The appearance of the capsules, and the packaging they come in may differ too.
But otherwise, both treatments contain the same active ingredient (orlistat) and work in very much the same way in the body.
Xenical vs Alli: which is better?
Answer:
Both treatments contain the same active ingredient, orlistat, and work in the same way. Alli stops about one quarter of the fat that you consume from being digested, whereas Xenical prevents around one third of the fat from being absorbed by the body. Alli also contains half the dosage of Xenical (60mg, as opposed to 120mg), which is why it removes less fat from the body.
Alli isn't currently available in Canada. But Xenical works in the same way and has the same active ingredient. So if you're interested in Alli, Xenical might be the one to try.
How long does Xenical take to work?
Answer:
This depends on many factors, but we’ll be able to monitor how it’s working for you and suggest any changes if they’re needed. If you’ve lost 5% of your weight within a three month period, there’s no threshold for how long Xenical will be prescribed for.
If you continue to lose weight beyond six months, our clinician may recommend that you keep taking Xenical. This may be for up to one or two years, or longer still if you have a significant amount of weight to lose.
What should I do if Xenical doesn’t work?
Answer:
Speak with your doctor. They can advise you on alternative weight loss treatments if Xenical isn’t effective for you.
It may be that making further changes to your diet and exercising on a regular basis may help. Our clinician may recommend that you keep a food diary and an activity diary for exercise to help them monitor your eating habits properly. Once our clinician has got this information to hand, they can help you to implement adjustments to your lifestyle and to create an action plan.
Is Xenical safe to use?
Answer:
For most people, Xenical is perfectly safe to use, [1] but it’s not suitable for everyone.
Losing weight can impact treatment doses for conditions such as diabetes and high cholesterol. If you’re using these medicines, it’s very important that you let us know.
If you’re on the birth control pill, it’s advisable to use additional contraception like condoms if you’re taking Xenical, as it can trigger severe diarrhea. This may compromise the effectiveness of oral contraception.
Xenical is not suitable for children.
Can I get Xenical over the counter?
Answer:
Xenical is a prescription-only treatment, so you’ll need to have a consultation with a clinician so they can assess if it’s suitable for you to use.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Why this page was updated on Jul 29, 2025
Content checked and updated as part of our 3-yearly periodic review, to ensure accuracy and currentness.
Current version (Jul 29, 2025)
Edited by: The Treated Content Team.Medically reviewed by: Ms Laurenmarie Cormier, Clinical Content Reviewer
Aug 01, 2022
Published by: The Treated Content Team.Medically reviewed by: Ms Laurenmarie Cormier, Clinical Content Reviewer
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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