Zyban
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Reviewed on Jul 24, 2025. by Ms Laurenmarie Cormier Clinical Content Reviewer Registered with NPI (No. 1700446366) Next review due on January 22, 2028.
Ms Laurenmarie Cormier

Last updated on Jul 24, 2025.

Product info

  • Zyban is a prescription pill to help you quit smoking by reducing cravings.
  • It’s taken daily for 7-9 weeks.
  • It can increase your chances of quitting compared to going cold turkey.

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Zyban Bupropion

What is Zyban?

Zyban is a medication that was originally developed to treat depression, but it was soon found to be an effective stop smoking treatment.

Stopping smoking can be hard, and you need willpower to make it work. But Zyban has been proven more effective than just quitting cold turkey.

It’s a pill you take everyday, and then a couple of times a day. In just nine weeks, it helps you beat nicotine addiction to become stronger and healthier.

How Zyban works

It’s not fully understood how Zyban works, but it’s likely that it works on the part of the brain that is affected by addictive behavior. By reducing the cravings associated with smoking, this can help make the process easier.

Using Zyban to quit smoking might not be suitable for everyone, but it can be of great benefit for many smokers who are struggling to quit.

How safe is Zyban?

Most people who use Zyban don’t experience significant side effects, but it’s important that you know what the risks are before starting treatment. You can find more info on these in the leaflet that comes with the medicine. But if you’re unsure or concerned about anything, just let us know, and we’ll answer any questions you have.

The most common severe symptom is seizures, which occur in less than one in 1,000 of users. If you do experience a seizure, stop taking Zyban and seek immediate medical help.

treated.com This page was written by The Treated Content Team.
Ms Laurenmarie Cormier 3760
This page was medically reviewed by Ms Laurenmarie Cormier on January 22, 2025. Next review due on January 22, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Zyban Bupropion

How should I take Zyban?

Swallow the tablets whole, without halving or crushing them. Not swallowing them whole will mean the active ingredient will be released all at once, increasing the risk of side effects and making the treatment less effective. Zyban should not be taken shortly before you go to bed as it may cause insomnia, but it can be taken with or without food.

Taking Zyban and smoking

Instructions for Zyban will be included with the medication and you should follow them carefully to get the best out of the treatment. As Zyban is taken before you stop smoking, some forward planning is needed.

How to take Zyban

Week 1
Days 1-6: Take one tablet once a day
Day 7 – Take one tablet, twice a day, eight hours apart (not close to bedtime).

Week 2
Stop smoking this week and continue taking one tablet, twice a day.

Week 3 to 9
Continue taking one tablet, twice a day.
If you haven’t stopped smoking by week 7, your clinician will recommend stopping treatment.

If you’re over 65, you might have a lower dose or take one tablet a day for the duration of the course.

If you haven’t managed to stop smoking during this time, let us know. It may be that a different treatment could work better, or that you need a little extra support to help you quit.

What should I do if I miss a dose?

If you forget to take a dose, simply carry on with the next scheduled tablet. Do not take double the dose to make up for the missed dose as this will only increase the risk of side effects.

treated.com This page was written by The Treated Content Team.
Ms Laurenmarie Cormier 3760
This page was medically reviewed by Ms Laurenmarie Cormier on January 22, 2025. Next review due on January 22, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Zyban Bupropion

There are some things you need to watch out for when using Zyban, and not everyone can use it.

Here’s the official safety info. If there’s something you’re not sure about, let us know.

Zyban Bupropion

Zyban: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

If I take too much Zyban, what should I do?

Answer:
If you take too much Zyban, seek immediate medical attention. An overdose of Zyban can lead to a greater risk of seizures, which can be dangerous.

It’s important to properly track what you have taken and when the next dose is due. You could try using a medication reminder app, to note down when you’ve taken your tablets. That can stop you from accidentally double-dosing.

What Zyban dosages are available and how do I use them?

Answer:
Zyban 150 mg are the only Zyban tablets available. Because it’s a slow-release tablet (tablets that release the active ingredient slowly), its levels can be maintained, offering steady support for stopping cravings.

If you’re over 65, have liver or kidney disease or if you’re more prone to seizures, you may need to take a lower dose of Zyban.

What’s the difference between Bupropion and Zyban?

Answer:
The active ingredient in Zyban is Bupropion, which is also the generic name for the treatment. In short, Bupropion and Zyban are the same medication, and they work in the same way.

The main differences are the lab that makes the tablets, the packaging and the price. Because Zyban is a branded treatment, it’s usually more expensive than the generic.

What should I do if I want to stop taking Zyban?

Answer:
Zyban is a seven week treatment and you won’t see all its effects right away. So if you stop taking it early, you won’t have the best shot at quitting smoking. If you feel like Zyban isn’t working for you, send us a message.

You may need to reduce the dosage slowly when you’re stopping Zyban. It’s important that you speak to our clinician about this in the first instance, so they can advise you on the safest way to do so.

Zyban or Champix: which is better?

Answer:
The two most commonly used prescription treatments for stopping smoking are Champix and Zyban. Although both essentially help reduce the cravings associated with quitting smoking, they work in different ways.

Zyban affects the part of the brain that’s related to addiction. Champix instead blocks how nicotine interacts with the receptors in the brain. It also releases dopamine, but to a lesser extent than Zyban. So they function differently, but provide similar results, at least in the long term. [1]

That’s not to say that they work the same for everyone. Finding the right treatment can vary from person to person, so there’s no one size fits all.

Can Zyban cause depression?

Answer:
As mood changes are a relatively common side effect of taking Zyban, it’s possible you may experience depression during the treatment. This usually goes away in a few weeks. But if you experience a significant change in mood, let our clinician know.

Is Zyban also helpful for weight loss?

Answer:
There is some evidence that Zyban can help in weight management, but it’s not precisely known why this happens. The effects are thought to be related to certain hormones in the body, [2] such as dopamine. In fact, bupropion is one of the active ingredients in the weight loss medication Contrave.

We only offer Zyban as a stop smoking treatment. But it may be preferable for someone who also has concerns about putting on weight as a result of quitting.

Are there any over the counter stop smoking aids?

Answer:
Yes. There are many stop smoking aids that can be bought over the counter. Most of these products work by replacing the nicotine without all the other chemicals that are found in tobacco.
These include patches, gums, nasal sprays and lozenges.

There are also vape products (E-cigarettes) that deliver nicotine. Results from these NRT (nicotine replacement therapies) are positive, [3] but some find they just prolong the addiction.

Does Zyban work better than quitting cold turkey?

Answer:
Cold turkey means to stop smoking without slowly reducing the intake of the substance that you’re addicted to. In other words, to just stop smoking.

Some studies suggest that cold turkey is more effective than gradually cutting down. [4] But treatments like Zyban have been shown to be more effective than cold turkey alone, with some studies suggesting that it doubles your chances of quitting successfully. [5]

Treated trusted source:

  1. Ramazan Benli, A. Et al. 2017. A comparison of the efficacy of varenicline and bupropion and an evaluation of the effect of the medications in the context of the smoking cessation programme. Tobacco Induced Disease U.S.A.
  2. Gadde. K.M. Et al. 2012. Bupropion for Weight Loss: An Investigation of Efficacy and Tolerability in Overweight and Obese Women. Obesity Research. U.S.A. Wiley Online Library.
  3. Heydari, G. Et al. 2014. A comparative study on tobacco cessation methods: a quantitative systematic review. Pubmed. 2014. N.I.H. U.S.A. P.M.C.
  4. Cheong, Y. Et al. 2007. Does How You Quit Affect Success? A Comparison Between Abrupt and Gradual Methods Using Data from the International Tobacco Control Policy Evaluation Study. Nicotine and Tobacco Research. U.K. Oxford Academic.
  5. Roddy, E. (2004). Bupropion and other non-nicotine pharmacotherapies. BMJ, 328(7438), pp.509–511.

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Further reading

Take a look at our helpful health guides related to stop smoking.

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